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    General information: [ref]

    Catapres (Clonidine Hydrochloride)Clonidine (trade names include Catapres; Arkamin; Atensina; Catapresan; Catapres-TTS; Clonidin Ratiopharm; Teva-Clonidine; Clonistada; Dixarit; Isoglaucon; Kapvay; Nexiclon-XR; Normopresan; Novo-Clonidine) is an antihypertensive, antimigraine, ophthalmological drug from sympathomimetics, antimigraine preparations, and imidazoline receptor agonists pharmacological groups. This medicine is used for the treatment of hypertension (high blood pressure), hypertensive emergency alone or with diuretics and other antihypertensive drugs. It works by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.
    Clonidine HCl in ophthalmic/eye drops pharmaceutical form is prescribed as sympathomimetic in glaucoma therapy.
    This medication is also indicated for migraine prevention, to treat migraines with or without aura, migraine headaches, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, tic disorders, impulse control disorder, restless legs syndrome (RLS), clozapine-induced sialorrhea, menopausal flushing (hot flashes associated with menopause), vasomotor symptoms associated with menopause, perimenopausal symptoms, dysmenorrhea (menstrual cramps, pain during menstruation), facial flushing and redness associated with rosacea, postherpetic neuralgia, severe pain, certain pain conditions, atrial fibrillation, postural orthostatic tachycardia syndrome, tardive dyskinesia, hyperhidrosis, ulcerative colitis; diarrhea associated with diabetes, irritable bowel syndrome (IBS), fecal incontinence, intestinal failure, withdrawal-associated diarrhea, neuroendocrine tumors and cholera; for pheochromocytoma diagnosis; to prevent oral mucositis in head and neck cancer patients undergoing radiation therapy.
    Catapres helps to relieve withdrawal symptoms from alcohol (ethanol dependence), benzodiazepines, dexmedetomidine, narcotics, heroin, opioids, nicotine (smoking cessation).
    Other off-label uses of Clonidine are include psychiatric disorders, stress, insomnia, sleep disorders, post-traumatic stress disorder (PTSD), borderline personality disorder, bipolar disorder, other anxiety disorders; as mild sedative drug; as premedication before surgery or procedures.
    Its topical and epidural forms (transdermal patches, plasters, TTS) are used and studied for pain relief during heart attack, postoperative and intractable pain, postanesthetic shivering, to treat diabetic neuropathy.


    Pharmacological and medical categories:

  • Alcohol dependence treatment
  • Anti stress pills
  • Antiglaucoma medications
  • Antihypertensive drugs
  • Antimigraine agents
  • Antisympathotonic agent
  • Anxiolytics
  • Centrally acting alpha-2 adrenergic agonists
  • Drug rehab
  • Drugs to treat withdrawal symptoms
  • Narcotic dependence treatment
  • Opioid dependence treatment
  • Ophthalmological preparations
  • Pain relief medicines
  • Postoperative care
  • Premedication drugs
  • Sedatives
  • Skin care products
  • Smoking cessation
  • Women's Health


    The Anatomical Therapeutic Chemical (ATC) classification system codes:

  • C - Cardiovascular system
  • C02 - Antihypertensives
  • C02A - Antiadrenergic agents, centrally acting
  • C02AC - Imidazoline receptor agonists
  • C02AC01 - Clonidine

  • N - Nervous system
  • N02 - Analgesics
  • N02C - Antimigraine preparations
  • N02CX - Other antimigraine preparations
  • N02CX02 - Clonidine

  • S - Sensory organs
  • S01 - Ophthalmologicals
  • S01E - Antiglaucoma preparations and miotics
  • S01EA - Sympathomimetics in glaucoma therapy
  • S01EA04 - Clonidine


    The International Statistical Classification of Diseases and Related Health Problems (World Health Organization, ICD-10) codes:

  • Cholera - A00
  • Zoster [herpes zoster] - B02
  • Other postherpetic nervous system involvement - B02.29
  • Malignant neuroendocrine tumors - C7A
  • Benign neoplasm of other and unspecified endocrine glands - D35
  • Diabetes mellitus - E08-E13
  • Type 2 diabetes mellitus - E11
  • Type 2 diabetes mellitus with diabetic neuropathy, unspecified - E11.40
  • Alcohol related disorders - F10
  • Opioid related disorders - F11
  • Sedative, hypnotic, or anxiolytic related disorders - F13
  • Nicotine dependence - F17
  • Bipolar disorder - F31
  • Reaction to severe stress, and adjustment disorders - F43
  • Post-traumatic stress disorder (PTSD) - F43.1
  • Specific personality disorders - F60
  • Borderline personality disorder - F60.3
  • Impulse disorders - F63
  • Attention-deficit hyperactivity disorders - F90
  • Tic disorder - F95
  • Tourette's disorder - F95.2
  • Dystonia - G24
  • Drug induced subacute dyskinesia - G24.01
  • Other extrapyramidal and movement disorders - G25
  • Restless legs syndrome - G25.81
  • Sleep disorders - G47
  • Insomnia - G47.0
  • Glaucoma - H40
  • Essential (primary) hypertension - I10
  • Hypertensive crisis - I16
  • Hypertensive urgency - I16.0
  • Atrial fibrillation and flutter - I48
  • Other cardiac arrhythmias - I49
  • Other specified cardiac arrhythmias - I49.8
  • Migraine - G43
  • Diseases of salivary glands - K11
  • Stomatitis and related lesions - K12
  • Oral mucositis (ulcerative) - K12.3
  • Ulcerative colitis - K51
  • Irritable bowel syndrome - K58
  • Intestinal malabsorption - K90
  • Rosacea - L71
  • Menopausal and other perimenopausal disorders - N95
  • Menopausal and female climacteric states - N95.1
  • Fecal incontinence - R15
  • Other symptoms and signs involving the digestive system and abdomen - R19
  • Pain, unspecified - R52
  • Generalized hyperhidrosis - R61
  • Encounter for procedures for purposes other than remedying health state - Z41
  • Problems related to life management difficulty - Z73
  • Stress, not elsewhere classified - Z73.3


    Pregnancy categories:

  • B3 - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms used as active pharmaceutical ingredients (API):

  • Clonidine Base
  • Clonidine Hydrochloride
  • Clonidine Tosylate


    Synonyms, international and chemical names:

  • 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-
  • 2,6-Dichloro-N-2-imidazolidinylidenebenzenamide
  • Chlornidinum
  • Clonidin
  • Clonidina
  • Clonidine HCl
  • Clonidinehydrochloride
  • Clonidinhydrochlorid
  • Clonidini Hydrochloridum
  • Clonidinum
  • Clorhidrato de Clonidina
  • Hidrocloruro de Clonidina
  • Klonidiin
  • Klonidiini
  • Klonidin
  • Klonidine
  • Klonidinhydroklorid
  • Klonidino
  • Klonidyna


    Derivatives used as APIs:

  • Apraclonidine


    Brands, generics, trade names in various countries:

  • Alphapres - Metrolink Pharma Phils; Metro Drug Distribution
  • Apo-Clonidine - Apotex; Hind Wing
  • Arkamin - Unichem Laboratories
  • Atensina - Boehringer Ingelheim
  • Catapres - Boehringer Ingelheim
  • Catapresan - Boehringer Ingelheim
  • Catapres-TTS - Boehringer Ingelheim
  • Clonidin - Ratiopharm
  • Clonidin Retard - Ratiopharm
  • Clonidina - Arena Group; Fulton Medicinali
  • Clonidine - Mylan; Pro Doc; Sandoz; Sanis Health; Teva
  • Clonistada - Stada
  • Clonnirit - Rafa Laboratories
  • Clophelin - Dalkhimpharm; Moskhimfarmpreparaty; Vifiteh
  • Dixarit - Boehringer Ingelheim
  • Duraclon - AAI Pharmaceuticals; Bioniche Pharma; Xanodyne Pharmaceuticals
  • Isoglaucon - Alcon; Agepha
  • Jenloga - Shionogi; Patheon
  • Kapvay - Shionogi
  • Nexiclon-XR - Tris Pharma
  • Normopresan - Rafa Laboratories
  • Novo-Clonidine - Novopharm
  • Paracefan - Boehringer Ingelheim


    Pharmaceutical drugs and active ingredients (APIs) used in health care in combinations with clonidine:

  • Bencyclane Fumarate
  • Bendroflumethiazide
  • Chlorthalidone
  • Cyclothiazide
  • Hydrochlorothiazide
  • Proxodolol
  • Triamterene


    Some other medications in the same pharmacological classes:

  • Aceon (Perindopril Erbumine)
  • Adalat (Nifedipine)
  • Altace (Ramipril)
  • Avalide (Irbesartan; Hydrochlorothiazide)
  • Avapro (Irbesartan)
  • Benicar (Olmesartan)
  • Betapace (Sotalol)
  • Calan (Verapamil)
  • Cardura (Doxazosin)
  • Cartia (Diltiazem HCl)
  • Colospa (Mebeverine)
  • Depakote (Divalproex)
  • Diovan (Valsartan)
  • Estulic (Guanfacine)
  • Euctan (Tolonidine)
  • Hyperium (Rilmenidine)
  • Hyzaar (Losartan; Hydrochlorothiazide)
  • Imigran (Sumatriptan)
  • Imitrex (Sumatriptan)
  • Inderal (Propranolol)
  • Lioresal (Baclofen)
  • Lopressor (Metoprolol)
  • Maxalt (Rizatriptan)
  • Mestinon (Pyridostigmine)
  • Norvasc (Amlodipine)
  • Physiotens (Moxonidine)
  • Requip (Ropinirole)
  • Robaxin (Methocarbamol)
  • Tenormin (Atenolol)
  • Topamax (Topiramate)
  • Vaseretic (Enalapril; Hydrochlorothiazide)
  • Vasotec (Enalapril)
  • Zanaflex (Tizanidine)
  • Zebeta (Bisoprolol)
  • Zestril (Lisinopril)


    Here is a list of popular medications containing clonidine as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Arkamin
  • Tablets; Oral; Clonidine Hydrochloride 0.1 mg
  • Unichem Laboratories
  • Catapres
  • Injectable; Infusion; Clonidine Hydrochloride 0.15 mg / ml
  • Injectable; Injection; Clonidine Hydrochloride 0.15 mg / ml
  • Tablets; Oral; Clonidine Hydrochloride 0.075 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.1 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.15 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.2 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.3 mg
  • Boehringer Ingelheim
  • German Remedies
  • Metro Drug Distribution
  • Navana Pharmaceuticals
  • Zydus Cadila
  • Catapresan
  • Injectable; Injection; Clonidine Hydrochloride 0.15 mg / ml
  • Tablets; Oral; Clonidine Hydrochloride 0.075 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.1 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.15 mg
  • Tablets; Oral; Clonidine Hydrochloride 0.3 mg
  • Boehringer Ingelheim
  • Delpharm
  • Euro Registratie
  • Fher Laboratorios
  • Unilfarma Uniao Internacional Laboratorios Farmaceuticos
  • Dixarit
  • Tablets, Sugar-Coated; Oral; Clonidine Hydrochloride 0.025 mg
  • Boehringer Ingelheim
  • B & S Healthcare
  • Delpharm
  • Diethelm
  • Expono
  • N.G.
  • Kapvay
  • Tablets, Extended Release; Oral; Clonidine Hydrochloride 0.1 mg
  • Tablets, Extended Release; Oral; Clonidine Hydrochloride 0.2 mg
  • Tablets, Extended Release; Oral; Clonidine Hydrochloride 0.3 mg
  • Shionogi
  • CJ HealthCare
  • Concordia Pharmaceuticals



  • References:

  • PubChem database with main scientific information about active pharmaceutical ingredients : https://pubchem.ncbi.nlm.nih.gov/
  • PubMed database on US National Library of Medicine, National Institutes of Health: https://www.ncbi.nlm.nih.gov/pubmed/
  • DrugBank database containing information on drugs and drug targets: https://www.drugbank.ca/
  • MedlinePlus - an online information service produced by the United States National Library of Medicine: https://medlineplus.gov/
  • WebMD - an online publisher of news and information pertaining to human health and well-being: https://www.webmd.com/
  • Medscape - a website providing access to medical information for physicians and health professionals: https://www.medscape.com/
  • DailyMed drug labels resource from U.S. National Library of Medicine: https://dailymed.nlm.nih.gov/dailymed/spl-resources-all-drug-labels.cfm
  • Mayo Clinic - a nonprofit academic medical center focused on integrated clinical practice, education, and research: https://www.mayoclinic.org/
  • Drugs@FDA: U.S. Food and Drug Administration approved drug products database: https://www.accessdata.fda.gov/scripts/cder/daf/
  • Drug Product Database online query from Health Canada: https://health-products.canada.ca/dpd-bdpp/index-eng.jsp
  • European Medicines Agency (EMA) website with "Search for medicines" tool for European Union countries: https://www.ema.europa.eu/en
  • UK drug database from electronic Medicines Compendium (eMC): https://www.medicines.org.uk/emc
  • Australian medicine finder from NPS MedicineWise: https://www.nps.org.au/medicine-finder
  • Agencia Espanola de Medicamentos y Productos Sanitarios - AEMPS: https://www.aemps.gob.es/
  • Pharma and medical DB in EU on CBG-MEB: https://www.cbg-meb.nl/
  • Huge database for drug search especially for european and Latin America region: https://www.vademecum.es/equivalencia
  • MyHealthbox - multilanguage search engine for official information on medicines and healthcare products: https://myhealthbox.eu/en/
  • Pharmaceutical and other healthcare databases in some countries, primarily across Asia Pacific: https://www.mims.com/
  • MIMS drug index in China: http://www.mims.com.cn/china/drug/index/
  • IndiaMart - Various exploring tools, including for medical and pharmaceutical products in India: https://dir.indiamart.com/
  • A to Z brands and generics with their comparative prices on MedGuideIndia: http://www.medguideindia.com/show_generics.php
  • Generic drugs with their brand names on Medindia: https://www.medindia.net/drug-price/index.asp
  • Online Drug Information System, primarily for India and Pakistan: http://www.druginfosys.com/
  • Medizzine - hispanic portal for medicines: http://www.medizzine.com/pacientes/medicamentos/index.php
  • English version of Medizzine - health & medicines portal: http://www.medizzine.com/en/patients/drugs/index.php
  • Search tools for medications on Japanese Orange Book: http://www.jp-orangebook.gr.jp/cgi-bin/search/search_e.cgi
  • South Korean PharmaLink gateway: http://www.pharmalink.kr/
  • Medicines brand and generic index for Africa region: https://daktariafrica.com/medicine/raw/index/
  • APIs database on Galinos: https://www.galinos.gr/web/drugs/main/substances
  • RLSNet index for drugs, nutritions and supplements in Russia, Eastern Europe and Middle Asia regions: https://www.rlsnet.ru/tn_alf.htm
  • Taiwan Food and Drug Administration: https://www.fda.gov.tw/TC/index.aspx
  • Online medicine information directory from MedEx: https://medex.com.bd/generics/
  • The Anatomical Therapeutic Chemical ATC/DDD Index 2019: https://www.whocc.no/atc_ddd_index/
  • International Statistical Classification of Diseases and Related Health Problems 10th Revision, WHO: https://www.icd10data.com/

    Updated: September, 2019



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